Advanced Mass Spectrometry Solutions

Metabolomics Services

From Complex Samples to Clear, Actionable Insights

LC-MS/MS and GC-MS metabolomics tailored to your study.
Share your matrix, targets, and timeline. We’ll define the right workflow and deliverables.

Discuss feasibility, study design, and turnaround time.

Comprehensive Metabolomics Workflows

We go beyond simple data acquisition. Our laboratory applies advanced LC-MS/MS and GC-MS workflows using high-resolution Orbitrap/Q-TOF platforms to address biological and translational research questions. Depending on molecular targets and study goals, we select the most appropriate platform and tailored protocols.

Metabolomics Approaches

Global Profiling

Untargeted Metabolomics

Purpose: Hypothesis generation and discovery-driven research.

Approach: Comprehensive metabolic profiling when you don’t yet know which compounds are important. We detect thousands of molecular features across your samples to identify what’s changing. This works well for biomarker discovery and exploratory studies where the biology and chemistry are not fully defined.

Ideal for: Biomarker discovery, exploratory studies, and system-level metabolic characterization.

Precision Quantification

Targeted Metabolomics

Purpose: Absolute quantification of predefined metabolites or pathways.

Approach: Quantitative measurement of specific metabolites using authentic standards. This includes building calibration curves for standards + performance metrics (LOQ, linearity, precision), critical for mechanistic studies, clinical validation, or any work where precise numbers matter. We validate each assay to ensure the measurements are robust.

Ideal for: Mechanistic studies, clinical validation, pharmacokinetics, and translational research.

Hybrid Approach

Semi-Targeted Metabolomics

Purpose: Combining focused questions with broader metabolic context.

Approach: A hybrid approach: a quantitative focus on specific metabolite classes (such as bile acids, amino acids, lipids, etc.) while maintaining broad coverage for context. Useful when there is a hypothesis, but also need to see what else might be relevant.

Ideal for: Studies requiring both coverage depth and contextual interpretation.

Diverse Biological Matrices

We tailor sample preparation, extraction, and chromatographic conditions to each biological matrix to ensure data quality and minimize matrix-specific interferences and biases.

Supported sample types include:

Custom Assay Development

When Standard Panels Are Not Enough

When predefined metabolomics panels cannot adequately address your research objectives, we develop custom LC-MS/MS and/or GC-MS assays tailored to your specific analytical requirements.

Custom assay development is particularly valuable for:

Our custom workflows may include:

Custom assays are typically implemented within targeted or semi-targeted metabolomics frameworks.

Advanced Data Processing & Biological Interpretation

We transform raw mass spectrometry data into biologically meaningful insights. Every project includes a structured data analysis pipeline:

Quality Control

Signal normalization and batch effect correction

Statistical Analysis

Multivariate and univariate methods (e.g., PCA, PLS-DA, differential analysis)

Functional Interpretation

Pathway mapping and enrichment analysis

Our team provides expert support to interpret results in the context of your specific research hypothesis or study design.

Why Partner with Arome Science?

We handle difficult matrices.

Your samples are unique, and we treat them that way. From plasma and stool to cell lysates and unconventional matrices, we’ve built optimized methods across a wide range of sample types, and we’re happy to figure it out together.

Custom assays when needed.

When standard panels fall short, we build what you need. Whether you’re tracking low-abundance metabolites or an emerging class of compounds, we develop targeted assays tailored to your research question.

You get the actual data.

And when the results are ready, they’re yours. We hand over everything – raw files, peak tables, full methods documentation, along with a clear explanation of what the data means in your research question’s context.

Ready to Start Your Analysis?

Contact us with your research question and sample types.
We’ll outline what’s feasible analytically and for a given budget.