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S’Wipe IQ
Gut Inflammation Panel

ELISA protein biomarkers from a S’Wipe collection

Same paper, same routine, single collection.

ISO 9001 & CLIA-certified laboratory • Research use only

Why Measure Gut Inflammation Proteins?

The intestinal lining and mucosal immune system release measurable proteins in response to inflammation, barrier disruption, and immune activation. These proteins can be detected in stool and are well studied in the context of inflammatory bowel disease (IBD), intestinal permeability, and mucosal immune function.

A targeted panel may provide research-grade information related to:

Mucosal inflammation: markers such as calprotectin and lactoferrin are associated with active intestinal inflammation in published studies
Gut barrier function: proteins such as zonulin are studied as indicators of tight junction integrity (interpretation remains an active research area)
Mucosal immune status: secretory IgA reflects local antibody production in the gut lining
Enterocyte integrity: I-FABP is elevated in conditions involving intestinal epithelial injury
Systemic immune signaling: LBP is associated with bacterial translocation and downstream inflammatory responses

When combined with short-chain fatty acid (SCFA) profiles (particularly butyrate), which plays an established role in gut barrier maintenance and mucosal immunity. These markers can provide a more integrated research perspective than either measurement alone.

No individual marker should be interpreted in isolation, and results should not be used for clinical decision-making without evaluation by a qualified clinician.

The Gut Inflammation Biomarker Panel

Panel composition subject to finalization. Representative markers shown.

All markers are measured from the same fecal S’Wipe collection. When ordered with S’Wipe metabolomics, results are automatically paired with fecal SCFA profile (butyrate, propionate, acetate).

Biomarker	What it measures	Research context
Calprotectin	Neutrophil-derived protein released during intestinal inflammation	The most extensively validated fecal marker of mucosal inflammation; elevated levels are associated with active IBD and Crohn's disease in numerous clinical studies
Lactoferrin	Antimicrobial protein released by activated neutrophils	Well-studied fecal inflammation marker; correlates with mucosal disease activity and is used in IBD research as a complement to calprotectin
Lysozyme	Antimicrobial enzyme secreted by neutrophils, macrophages, and Paneth cells	A marker of innate immune activation in the gut; elevated fecal levels reflect granulocyte and macrophage infiltration and have been studied alongside calprotectin and lactoferrin in the context of intestinal inflammation and IBD activity
Secretory IgA	Primary antibody mediating mucosal immune defense	Reflects the activity of the gut-associated immune system; studied in the context of mucosal immunity, gut dysbiosis, and immune suppression
Pancreatic Elastase	Protease secreted by the exocrine pancreas and measured in stool as a proxy for pancreatic output	A well-validated, non-invasive marker of exocrine pancreatic function; low fecal levels are associated with pancreatic exocrine insufficiency (PEI) and are used in research on maldigestion, chronic pancreatitis, and related conditions
Beta-Glucuronidase (Functional)	Bacterial enzyme activity reflecting microbial metabolism of glucuronide conjugates in the gut	Produced primarily by gut microbiota; elevated activity has been studied in the context of dysbiosis, estrogen recycling, colon cancer risk, and toxin reactivation from conjugated compounds
Occult Blood / Hemoglobin	Trace amounts of blood in stool not visible to the naked eye	A clinically established screening marker for gastrointestinal bleeding; detected via fecal immunochemical testing (FIT) and used extensively in colorectal cancer screening research and the evaluation of mucosal injury

Understanding Your Results

Results are reported as quantitative concentrations with reference ranges drawn from peer-reviewed literature. Out-of-range values are flagged, and a plain-language summary explains each measurement in the context of current research.

This panel may be of research interest in the context of:

This panel is a research-grade measurement service. Results are not intended to diagnose, treat, or screen for any medical condition. Any result that raises concern, particularly a pattern of elevated inflammation markers combined with disrupted SCFA levels, should be discussed with a gastroenterologist or other qualified clinician who can evaluate it in the context of your full clinical picture.

Who is this for?

For individuals:

Anyone interested in understanding their gut health markers in a research context. Collection is done at home using S’Wipe – no clinic visit, no cold shipping. Results are accompanied by a research summary and reference ranges, and are intended to be shared with your healthcare provider for any clinical follow-up.

For researchers and clinicians (B2B):

Purpose-built for academic and clinical research teams conducting gut health studies, dietary interventions, or longitudinal microbiome cohort studies. The ELISA protein quantification from a S’Wipe collection reduces participant burden and simplifies biospecimen logistics without sacrificing data quality. Arome Science’s ISO 9001 and CLIA certifications support use in regulated research environments. Bulk pricing and custom panel configurations are available upon request.

How It Works

S’Wipe IQ (Inflammation Quantitation) works with the S’Wipe stool collection kit

Collect

Collect using the standard S’Wipe kit (no additional sampling steps).

Stabilize

Stabilize proteins and metabolites together in a single sample.

Measure

Measure inflammation-related proteins by ELISA.

Why this works

Your sample is processed in a specialized stabilization buffer developed with our partner IDK GmbH. The buffer preserves proteins, enabling ELISA-based protein quantification.

When ordered with S’Wipe metabolomics, results are automatically paired with fecal SCFA profiles (butyrate, propionate, acetate).

Quality & Compliance

ISO 9001-certified quality management system
CLIA-certified laboratory

What is ELISA?

ELISA (Enzyme-Linked Immunosorbent Assay) is a widely used analytical method for measuring the amount of specific proteins in biological samples. Antibodies bind selectively to a target protein, and the signal generated is proportional to its concentration. This allows for quantitative, reproducible measurement rather than a qualitative positive/negative result.

ELISA is the method behind clinically established fecal tests such as calprotectin measurement, which is a standard tool in gastroenterology research and clinical practice. The markers in this panel use the same analytical principle, applied to a broader set of gut health proteins.

All measurements are reported as concentrations against validated reference ranges. Results are intended to inform research interpretation and support conversations with qualified clinicians and do not constitute a clinical diagnosis.

Order the Gut Inflammation Panel

Available as a standalone add-on to any S’Wipe metabolomics order, or as a bundled Gut Health + Inflammation kit.

All measurements are performed in Arome Science’s ISO 9001-certified and CLIA-certified laboratory. This service is intended for research use only and is not approved for clinical diagnostic use. Results should not be used as the basis for clinical decisions without evaluation by a qualified healthcare professional.

S’Wipe IQ Gut Inflammation Panel